RECHARGE

RECHARGE — METHYLCOBALAMIN B12 (500MCG) AND L-5-METHYLTETRAHYDROFOLATE (L-5-MTHF) — NEUROTRANSMITTER SYNTHESIS COFACTORS

These two ingredients are inseparable in function and must be understood together.

Methylcobalamin is the neurologically active form of Vitamin B12 — the form the nervous system actually uses, as distinct from the cheaper and less bioavailable cyanocobalamin found in most supplements. Its role in neurotransmitter synthesis is direct and well-established: Methylcobalamin serves as a cofactor in the methylation cycle that produces S-adenosylmethionine (SAMe) — the methyl donor required for the synthesis of serotonin, dopamine, and norepinephrine. A 2009 report from Harvard Medical School noted that folate is required for the synthesis of all three of these neurotransmitters. The neurological consequences of Methylcobalamin insufficiency — reduced neurotransmitter production, impaired myelin maintenance, and elevated homocysteine — are well-documented across the clinical literature.

L-5-Methyltetrahydrofolate (L-5-MTHF) is the biologically active form of folate — the form the brain can directly utilise, as distinct from the synthetic folic acid found in standard supplements. Critically, a significant proportion of the population carries genetic variants that impair the conversion of dietary folate to its active form, meaning that standard folate supplementation provides no neurological benefit for these individuals. L-5-MTHF bypasses this conversion entirely.

Together, Methylcobalamin and L-5-MTHF form the functional core of the methylation cycle that governs neurotransmitter synthesis, homocysteine clearance, and neurological performance. RECHARGE uses both in their active, bioavailable forms — not the cheaper alternatives that cannot perform these functions in the brain.

RECHARGE — PYRIDOXAL-5-PHOSPHATE (P5P) — ACTIVE VITAMIN B6

Pyridoxal-5-Phosphate is the active coenzyme form of Vitamin B6 — the cofactor required at a critical step in both serotonin and dopamine synthesis. Without adequate P5P, the enzymatic conversion of the amino acid precursors L-DOPA and 5-HTP into dopamine and serotonin respectively cannot proceed efficiently. Standard Vitamin B6 (pyridoxine) must be converted to P5P in the liver before it can function — a conversion that is impaired under conditions of metabolic stress and liver burden. RECHARGE provides P5P directly, bypassing that conversion entirely.

RECHARGE — L-TYROSINE — DOPAMINE PRECURSOR

L-Tyrosine is the direct amino acid precursor to dopamine, norepinephrine, and epinephrine — the catecholamine neurotransmitters governing motivation, focus, and executive function. Under conditions of caloric restriction, dietary protein intake — and with it, the availability of tyrosine — is reduced precisely when neurological demand is highest. L-Tyrosine supplementation provides the raw material for catecholamine synthesis without depending on dietary protein intake to deliver it.

RECHARGE — RHODIOLA ROSEA EXTRACT (STD. 3% ROSAVINS & 1% SALIDROSIDES) — ADAPTOGENIC CORTISOL MODULATION

The standardisation of Rhodiola rosea to specific Rosavin and Salidroside concentrations matters — these are the active compounds responsible for its documented adaptogenic effects, and unstandardised extracts cannot deliver them consistently.

A randomised, double-blind, placebo-controlled clinical trial published in Planta Medica found that repeated administration of standardised Rhodiola rosea extract produced a significant anti-fatigue effect, increased mental performance and concentration, and — critically — decreased the cortisol response to awakening stress in patients with burnout and fatigue syndrome. A 2022 systematic review published in Nutrients confirmed Rhodiola's documented benefits across cognitive function, mental fatigue, physical performance, and mood state in clinical populations experiencing stress-related conditions.

The mechanism is specific: Rhodiola rosea inhibits the stress-activated protein kinases that regulate the cellular response to stress, modulating the HPA axis and normalising cortisol output. Elevated cortisol — the predictable consequence of sustained caloric restriction and metabolic stress — suppresses the same neurotransmitter pathways that RECHARGE's B vitamin and amino acid complex is designed to support. Rhodiola addresses the hormonal upstream. The B vitamins and L-Tyrosine address the biochemical downstream. Together they work on the same problem from both directions.

RECHARGE — COENZYME Q10 (COQ10) — MITOCHONDRIAL ENERGY PRODUCTION

Every cognitive process — every neurotransmitter synthesis reaction, every neuronal signal — requires cellular energy. That energy is produced in the mitochondria, and CoQ10 is the rate-limiting cofactor in that process. During periods of caloric restriction and metabolic stress, CoQ10 availability declines. The result is reduced mitochondrial efficiency — a systemic reduction in cellular energy output that manifests as the persistent, unshakeable fatigue that characterises the post-GLP-1 experience.

RECHARGE — MAGNESIUM GLYCINATE — NEUROLOGICAL CALM

Magnesium is the fourth most abundant mineral in the body and is involved in over 300 enzymatic reactions — including several directly involved in neurotransmitter regulation and neurological function. Magnesium Glycinate is the most bioavailable oral form, with superior absorption compared to magnesium oxide or citrate. Its specific relevance in the GLP-1 context is the documented depletion of magnesium under conditions of reduced food intake — a depletion that directly impairs neurological function and sleep quality, both of which are central to cognitive recovery.